Erleada (apalutamide) vs Entadfi (finasteride and tadalafil)
Erleada (apalutamide) vs Entadfi (finasteride and tadalafil)
Erleada (apalutamide) is an androgen receptor inhibitor specifically approved for the treatment of non-metastatic castration-resistant prostate cancer, working by blocking the effect of androgens to slow the growth of prostate cancer. Entadfi, on the other hand, combines finasteride, a 5-alpha-reductase inhibitor that reduces the size of the prostate gland, with tadalafil, which is used to treat erectile dysfunction and alleviate urinary symptoms. When deciding between the two, a patient must consider their specific condition: Erleada is for cancer management, whereas Entadfi is used to treat benign prostatic hyperplasia (BPH) symptoms and associated erectile dysfunction, and is not indicated for prostate cancer treatment.
Difference between Erleada and Entadfi
| Metric | Erleada (apalutamide) | Entadfi (finasteride and tadalafil) |
|---|---|---|
| Generic name | Apalutamide | Finasteride and Tadalafil |
| Indications | Non-metastatic castration-resistant prostate cancer (nmCRPC), metastatic castration-sensitive prostate cancer (mCSPC) | Benign prostatic hyperplasia (BPH) |
| Mechanism of action | Androgen receptor inhibitor | Finasteride: 5-alpha-reductase inhibitor, Tadalafil: Phosphodiesterase type 5 (PDE5) inhibitor |
| Brand names | Erleada | Entadfi |
| Administrative route | Oral | Oral |
| Side effects | Fatigue, hypertension, rash, diarrhea, nausea, weight loss, arthralgia, falls, hot flush, decreased appetite, fractures, peripheral edema | Dizziness, hypotension, headache, flushing, nasal congestion, back pain, dyspepsia, pain in extremity |
| Contraindications | Pregnancy, severe hepatic impairment | Hypersensitivity to finasteride or tadalafil, concomitant nitrates use, severe renal impairment |
| Drug class | Antiandrogen | Finasteride: 5-alpha-reductase inhibitor, Tadalafil: PDE5 inhibitor |
| Manufacturer | Janssen Pharmaceuticals | Teva Pharmaceuticals |
Efficacy
Erleada (Apalutamide) for Prostate Cancer
Erleada, with the active ingredient apalutamide, is a medication approved for the treatment of prostate cancer. Specifically, it is indicated for patients with non-metastatic castration-resistant prostate cancer (nmCRPC). The efficacy of Erleada was demonstrated in a pivotal clinical trial known as SPARTAN, which showed that apalutamide significantly extended metastasis-free survival compared to placebo. Patients treated with Erleada had a median metastasis-free survival of over two years longer than those who received a placebo, marking a substantial improvement in delaying the progression of prostate cancer in this patient population.
In addition to its use in nmCRPC, Erleada has also been approved for the treatment of metastatic castration-sensitive prostate cancer (mCSPC). Clinical trials have indicated that when used in combination with androgen deprivation therapy (ADT), apalutamide can improve survival outcomes for men with this type of prostate cancer. The efficacy in this setting was supported by the results of the TITAN study, which showed that the combination of Erleada and ADT significantly reduced the risk of death compared to ADT alone.
Entadfi (Finasteride and Tadalafil) for Prostate Cancer
Entadfi is a combination medication that contains finasteride and tadalafil, which is not specifically approved for the treatment of prostate cancer. Finasteride is primarily used to treat benign prostatic hyperplasia (BPH), and it works by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), a hormone that can contribute to prostate growth. While finasteride has been studied for its potential role in prostate cancer prevention, it is not a standard treatment for prostate cancer itself.
Tadalafil, the other component of Entadfi, is a phosphodiesterase type 5 (PDE5) inhibitor commonly used to treat erectile dysfunction and the symptoms of BPH. Its role in the management of prostate cancer is not established, and there is no significant evidence to suggest that tadalafil alone or in combination with finasteride is effective for the treatment of prostate cancer. Therefore, while Entadfi may have applications in managing symptoms associated with BPH, its efficacy in the context of prostate cancer has not been substantiated by clinical trials specific to this disease.
Regulatory Agency Approvals
Erleada
-
European Medical Agency (EMA), European Union
-
Food and Drug Administration (FDA), USA
-
Health Canada
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Therapeutic Goods Administration (TGA), Australia
Entadfi
-
Food and Drug Administration (FDA), USA
Access Erleada or Entadfi today
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